Of Escambia County’s 79 precincts, only Pensacola Christian College voted against Amendment 2. Here are the precincts listed by largest margins for the Medical Marijuana amendment.
| Precinct | Location | Yes | No | Margin |
| PRECINCT 67 | HOLY SPIRIT CATHOLIC CHURCH | 3,007 | 1,107 | 1,900 |
| PRECINCT 26 | ST ANNES CATH CHURCH FAM CNTR | 3,102 | 1,223 | 1,879 |
| PRECINCT 112 | HILLCREST BAPTIST CHURCH | 3,395 | 1,534 | 1,861 |
| PRECINCT 105 | PERDIDO BAY UNITED METHODIST | 2,570 | 757 | 1,813 |
| PRECINCT 43 | BEULAH FREE WILL BAPTIST | 3,351 | 1,574 | 1,777 |
| PRECINCT 91 | OLIVE BAPTIST CHURCH | 2,808 | 1,130 | 1,678 |
| PRECINCT 1 | PLEASANT GROVE BAPTIST CHURCH | 2,419 | 750 | 1,669 |
| PRECINCT 107 | FAITH BAPTIST CHURCH | 2,396 | 797 | 1,599 |
| PRECINCT 98 | MACEDONIA BAPTIST CHURCH | 1,903 | 457 | 1,446 |
| PRECINCT 73 | BAILEY MIDDLE SCHOOL | 2,069 | 665 | 1,404 |
| PRECINCT 108 | HOLY CROSS EPISCOPAL CHURCH | 2,043 | 671 | 1,372 |
| PRECINCT 69 | ST JAMES MISSIONARY BAPTIST CHURCH | 2,151 | 797 | 1,354 |
| PRECINCT 75 | PENSACOLA BAPTIST TEMPLE | 2,063 | 732 | 1,331 |
| PRECINCT 3 | MYRTLE GROVE UNITED METHODIST | 1,940 | 642 | 1,298 |
| PRECINCT 24 | WARRINGTON UNITED METHODIST | 1,909 | 616 | 1,293 |
| PRECINCT 7 | PINEWOODS PRESBYTERIAN CHURCH | 2,724 | 1,456 | 1,268 |
| PRECINCT 51 | PENSACOLA LODGE #42 F&AM | 1,857 | 668 | 1,189 |
| PRECINCT 41 | BAYVIEW SENIOR RESOURCE CENTER | 1,431 | 299 | 1,132 |
| PRECINCT 94 | PENSACOLA BEACH COMM CHURCH | 1,669 | 543 | 1,126 |
| PRECINCT 74 | ESCAMBIA CO EXTENSION OFFICE | 2,649 | 1,526 | 1,123 |
| PRECINCT 38 | GONZALEZ UNITED METHODIST | 2,050 | 943 | 1,107 |
| PRECINCT 34 | MONTCLAIR ELEMENTARY SCHOOL | 1,399 | 315 | 1,084 |
| PRECINCT 86 | PINE SUMMIT BAPTIST CHURCH | 1,582 | 564 | 1,018 |
| PRECINCT 61 | ELKS LODGE BPOE #2108 | 1,468 | 460 | 1,008 |
| PRECINCT 28 | DAMASCUS ROAD MISSIONARY BAPTIST | 1,384 | 377 | 1,007 |
| PRECINCT 35 | EAST PENSACOLA HEIGHTS COMM CTR | 1,364 | 370 | 994 |
| PRECINCT 62 | CHARITY CHAPEL CHURCH | 1,626 | 640 | 986 |
| PRECINCT 83 | FIRST BAPTIST CHURCH OF WARRINGTON | 1,291 | 349 | 942 |
| PRECINCT 104 | MAYFAIR COMMUNITY CENTER | 1,187 | 278 | 909 |
| PRECINCT 42 | COKESBURY CHURCH SUMMIT BLVD | 1,598 | 719 | 879 |
| PRECINCT 111 | ST LUKE UNITED METHODIST | 1,618 | 743 | 875 |
| PRECINCT 14 | FRICKER COMMUNITY CENTER | 1,188 | 317 | 871 |
| PRECINCT 77 | LEXINGTON TERRACE COMM CNTR | 1,116 | 246 | 870 |
| PRECINCT 70 | WOODHAM MIDDLE SCHOOL | 1,444 | 577 | 867 |
| PRECINCT 103 | LAKEVIEW BAPTIST CHURCH | 1,185 | 338 | 847 |
| PRECINCT 64 | COKESBURY UNITED METHODIST | 1,407 | 563 | 844 |
| PRECINCT 19 | BARRINEAU PARK COMMUNITY CNTR | 1,908 | 1,079 | 829 |
| PRECINCT 46 | TRINITY PRESBYTERIAN CHURCH | 1,444 | 619 | 825 |
| PRECINCT 31 | CHRIST CHURCH PENSACOLA | 1,072 | 255 | 817 |
| PRECINCT 36 | QUINTETTE COMMUNITY CENTER | 1,548 | 740 | 808 |
| PRECINCT 21 | INTERNATIONAL PAPER | 1,378 | 577 | 801 |
| PRECINCT 15 | COUNTY GOVERNMENT COMPLEX | 1,448 | 653 | 795 |
| PRECINCT 56 | LEGION FIELD RESOURCE CENTER | 1,013 | 220 | 793 |
| PRECINCT 88 | UNIVERSITY PINES RETIREMENT | 1,219 | 428 | 791 |
| PRECINCT 30 | VICKREY COMMUNITY CENTER | 1,338 | 584 | 754 |
| PRECINCT 49 | GRACE LUTHERAN CHURCH | 1,030 | 280 | 750 |
| PRECINCT 95 | PERDIDO BAY BAPTIST CHURCH | 1,135 | 393 | 742 |
| PRECINCT 71 | WARRINGTON PRESBYTERIAN | 997 | 273 | 724 |
| PRECINCT 102 | MARCUS POINTE BAPTIST CHURCH | 1,305 | 587 | 718 |
| PRECINCT 5 | PINE FOREST UNITED METHODIST | 1,522 | 834 | 688 |
| PRECINCT 54 | ELKS LODGE BPOE #2108 | 1,183 | 502 | 681 |
| PRECINCT 55 | BLUE ANGELS ELEMENTARY SCHOOL | 1,118 | 439 | 679 |
| PRECINCT 40 | BAYVIEW SENIOR RESOURCE CENTER | 967 | 291 | 676 |
| PRECINCT 68 | PENS INTERSTATE FAIRGROUNDS | 1,171 | 504 | 667 |
| PRECINCT 29 | MT OLIVE MISSIONARY BAPTIST | 856 | 198 | 658 |
| PRECINCT 48 | COUNTY CENTRAL OFFICE COMPLEX | 867 | 215 | 652 |
| PRECINCT 90 | ST JOHN DIVINE BAPTIST CHURCH | 799 | 158 | 641 |
| PRECINCT 106 | GRACE LUTHERAN CHURCH | 1,018 | 392 | 626 |
| PRECINCT 47 | FRIENDSHIP MISSIONARY BAPTIST CHURCH | 783 | 170 | 613 |
| PRECINCT 101 | PLAINVIEW BAPTIST CHURCH | 1,034 | 432 | 602 |
| PRECINCT 97 | VICKREY COMMUNITY CENTER | 991 | 412 | 579 |
| PRECINCT 6 | ST MONICA’S EPISCOPAL CHURCH | 914 | 394 | 520 |
| PRECINCT 99 | MYRTLE GROVE BAPTIST CHURCH | 789 | 316 | 473 |
| PRECINCT 82 | FRIENDSHIP MISSIONARY BAPTIST CHURCH | 517 | 92 | 425 |
| PRECINCT 63 | MARIE K. YOUNG WEDGEWOOD COMM CNTR | 600 | 179 | 421 |
| PRECINCT 60 | EBONWOOD COMMUNITY CENTER | 549 | 130 | 419 |
| PRECINCT 113 | ESCAMBIA EDUCATION ASSOC | 758 | 348 | 410 |
| PRECINCT 80 | MYRTLE GROVE BAPTIST CHURCH | 578 | 217 | 361 |
| PRECINCT 72 | ST CHRISTOPHER’S EPISCOPAL CHURCH | 501 | 152 | 349 |
| PRECINCT 50 | MALCOLM YONGE CENTER | 363 | 70 | 293 |
| PRECINCT 22 | CENTURY CITY HALL | 482 | 198 | 284 |
| PRECINCT 58 | BRIT AHM MESSIANIC SYNAGOGUE | 556 | 275 | 281 |
| PRECINCT 25 | AZALEA TRACE ADMIN/INFO BUILDING | 648 | 368 | 280 |
| PRECINCT 32 | SANDERS BEACH-CORINNE JONES CTR | 327 | 85 | 242 |
| PRECINCT 11 | WALNUT HILL COMMUNITY CENTER | 531 | 330 | 201 |
| PRECINCT 18 | RAY’S CHAPEL BAPTIST CHURCH | 278 | 169 | 109 |
| PRECINCT 33 | FIRST BAPTIST CHURCH OF BRATT | 507 | 409 | 98 |
| PRECINCT 23 | BYRNEVILLE COMMUNITY CENTER | 354 | 270 | 84 |
| PRECINCT 110 | PCC MULLENIX CHAPEL/FELLOWSHIP HALL | 627 | 1,230 | -603 |